Bioinformatical Analysis of HGPRT Transferase from Different Malaria Parasite Plasmodium spp. Using Computational Tools

Authors

  • Nahla Osman Mohamed Ali University of Khartoum

DOI:

https://doi.org/10.18034/mjmbr.v4i2.430

Keywords:

HGPRT, Phosphoribosyl transferase, Plasmodium spp., Bioinformatics, Secondary structure

Abstract

In this study, HGPRT transferases from different malaria parasite Plasmodium species was analyzed and presented in this communication. The composition of leucine, lysine and Isoleucine were the highest while lowest concentrations of tryptophan and glutamine residues were noticed when compared to other amino acids. pI value of P. reichenowi HGPRT was 7.59 while the lowest pI of 6.22 was shown by P. chabaudi HGPRT. The instability index of all the transferases is varied, but for all of them it was less than 40, which indicates that all of them are stable. The aliphatic index was found to span within a range of 83 to 97. Secondary structural analysis of the transferases showed the pre-dominance of random coils followed by extended strands for all the transferases except P. falciparum, P. Knowlesi and P. reichenowi HGPRT transferase. The significance of the above results is discussed in the light of existing literature.

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Author Biography

  • Nahla Osman Mohamed Ali, University of Khartoum

    Department of Parasitology, Faculty of Veterinary Medicine, University of Khartoum, Khartoum North 13314, SUDAN

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Published

2017-12-31

Issue

Vol. 4 No. 2 (2017): July - December Issue

Section

Peer-reviewed Article

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How to Cite

Ali, N. O. M. . (2017). Bioinformatical Analysis of HGPRT Transferase from Different Malaria Parasite Plasmodium spp. Using Computational Tools. Malaysian Journal of Medical and Biological Research, 4(2), 85-90. https://doi.org/10.18034/mjmbr.v4i2.430
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