Antioxidant and Subchronic Toxicity Study of Myrmecodia Platytyrae (MyP) Water Extract

Authors

  • M. K. Nik Hasan UITM
  • I. Abdul Wahab UITM
  • H. H. Mizaton UITM
  • M. A. Rasadah FRIM
  • L. Abd Rashid FRIM
  • S. M. A. Nurul Hafizatul FRIM
  • M. A. Azman FRIM
  • H. Iyad Amir FRIM
  • B. Y. Isham FRIM

DOI:

https://doi.org/10.18034/mjmbr.v7i1.487

Keywords:

Myrmecodia  platytyrae, antioxidant, safety  and  sub-chronic  toxicity

Abstract

In this study, Myrmecodia platytyrae (MyP) water extract was investigated to explain the antioxidant property and its safety. Water extract of MyP was prepared and tested for ORAC for each batch of preparations. The MyP water extract was administered daily onto three groups of experimental animals which were Low Dose (LD), Medium Dose (MD) and High Dose (HD) groups for a period of consecutive 28 days according to the OECD GLP guideline (OECD TG 407). The ORAC results showed that MyP water extract has an antioxidant activity for each batch. The subchronic toxicity test showed that MyP water extract product has no observable sub-chronic toxic effect on Sprague Dawley rats. The body weight of rats increased along with proportional food and water intake. In the same way, all hematological, biochemical parameters as well as histopathological observation do not show any abnormal finding. Gross observations, feed and water consumption, urine strip test and animals’ weight during necropsy did not show any difference compared to the control group. In conclusion, MyP water extract is suggested to have a broad safety margin in experimental animals.

 

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Author Biographies

  • M. K. Nik Hasan, UITM

    Faculty of Pharmacy, Universiti Teknologi MARA (UITM), Bandar Puncak Alam, Selangor, 42300, MALAYSIA

  • I. Abdul Wahab, UITM

    Faculty of Pharmacy, Universiti Teknologi MARA (UITM), Bandar Puncak Alam, Selangor, 42300, MALAYSIA

  • H. H. Mizaton, UITM

    Faculty of Pharmacy, Universiti Teknologi MARA (UITM), Bandar Puncak Alam, Selangor, 42300, MALAYSIA

  • M. A. Rasadah, FRIM

    Makmal Isyarat Sel dan RTPCR, Program Bioaktiviti, Bahagian Hasilan Semulajadi, Forest Research Institute Malaysia (FRIM), 52109 Kepong, Selangor, Darul Ehsan, MALAYSIA

  • L. Abd Rashid, FRIM

    Makmal Isyarat Sel dan RTPCR, Program Bioaktiviti, Bahagian Hasilan Semulajadi, Forest Research Institute Malaysia (FRIM), 52109 Kepong, Selangor, Darul Ehsan, MALAYSIA

  • S. M. A. Nurul Hafizatul, FRIM

    Makmal Isyarat Sel dan RTPCR, Program Bioaktiviti, Bahagian Hasilan Semulajadi, Forest Research Institute Malaysia (FRIM), 52109 Kepong, Selangor, Darul Ehsan, MALAYSIA

  • M. A. Azman, FRIM

    Makmal Isyarat Sel dan RTPCR, Program Bioaktiviti, Bahagian Hasilan Semulajadi, Forest Research Institute Malaysia (FRIM), 52109 Kepong, Selangor, Darul Ehsan, MALAYSIA

  • H. Iyad Amir, FRIM

    Makmal Isyarat Sel dan RTPCR, Program Bioaktiviti, Bahagian Hasilan Semulajadi, Forest Research Institute Malaysia (FRIM), 52109 Kepong, Selangor, Darul Ehsan, MALAYSIA

  • B. Y. Isham, FRIM

    Makmal Isyarat Sel dan RTPCR, Program Bioaktiviti, Bahagian Hasilan Semulajadi, Forest Research Institute Malaysia (FRIM), 52109 Kepong, Selangor, Darul Ehsan, MALAYSIA

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Published

2020-04-03

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Peer-reviewed Article

How to Cite

Hasan, M. K. N. ., Wahab, I. A. ., Mizaton, H. H. ., Rasadah, M. A. ., Rashid, L. A. ., Hafizatul, S. M. A. N. ., Azman, M. A. ., Amir, H. I. ., & Isham, B. Y. . (2020). Antioxidant and Subchronic Toxicity Study of Myrmecodia Platytyrae (MyP) Water Extract. Malaysian Journal of Medical and Biological Research, 7(1), 37-48. https://doi.org/10.18034/mjmbr.v7i1.487