Antioxidant and Subchronic Toxicity Study of Myrmecodia Platytyrae (MyP) Water Extract
DOI:
https://doi.org/10.18034/mjmbr.v7i1.487Keywords:
Myrmecodia platytyrae, antioxidant, safety and sub-chronic toxicityAbstract
In this study, Myrmecodia platytyrae (MyP) water extract was investigated to explain the antioxidant property and its safety. Water extract of MyP was prepared and tested for ORAC for each batch of preparations. The MyP water extract was administered daily onto three groups of experimental animals which were Low Dose (LD), Medium Dose (MD) and High Dose (HD) groups for a period of consecutive 28 days according to the OECD GLP guideline (OECD TG 407). The ORAC results showed that MyP water extract has an antioxidant activity for each batch. The subchronic toxicity test showed that MyP water extract product has no observable sub-chronic toxic effect on Sprague Dawley rats. The body weight of rats increased along with proportional food and water intake. In the same way, all hematological, biochemical parameters as well as histopathological observation do not show any abnormal finding. Gross observations, feed and water consumption, urine strip test and animals’ weight during necropsy did not show any difference compared to the control group. In conclusion, MyP water extract is suggested to have a broad safety margin in experimental animals.
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