Protective Effects of Ferulic Acid in Alcohol Withdrawal Induced Anxiety and Depression in Mice
DOI:
https://doi.org/10.18034/mjmbr.v4i1.427Keywords:
Anxiolytic, Antidepressant, Ethanol withdrawal symptoms, Ferulic acidAbstract
Background: Anxiety and depression are the most important troubling symptoms of continuous alcoholism. Objective: The present study was designed to examine the protective effects of ferulic acid in alcohol withdrawal-induced anxiety and depression in experimental mice.
Methods: Male albino mice were divided into different groups. They were received 10% ethanol (2 g/kg; p.o.) twice on the first day and once on successive days for total six days, after 24 hrs. Withdrawal symptoms were observed using the different model for anxiety and depression such as elevated plus maze, open field test, hole board test, marble burying test and tail suspension test. Ferulic acid was tested as 10 and 20 mg/ kg, orally.
Results: Treatment with ferulic acid (10 and 20 mg/kg, p.o) showed significant reduction of alcohol withdrawal syndromes in different models. Taken together our result showed a protective effect in alcohol withdrawal anxiety and depression as tested in well-established animal models.
Conclusion: The present study showed that ferulic acid dose-dependently prevents alcohol withdrawal-induced anxiety and depression in mice.
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